{"product_id":"cd204-polyclonal-antibody-ra22971","title":"CD204 Polyclonal Antibody - RA22971","description":"CD204 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA22971-50, RA22971-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: macrophage scavenger receptor 1 (MSR1) Homo sapiens This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs) . The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000\n\nAlternative Names: Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II;Scavenger receptor class A member 1;CD antigen CD204) \n\nApplications: IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse; Rat\n\nGeneID (Human): 4481\n\nSWISS: P21757\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45119734481075,"sku":"RA22971-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45119734513843,"sku":"RA22971-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_5a675740-317f-46b7-a0d7-926251b88769.png?v=1773356412","url":"https:\/\/afsbio.com\/products\/cd204-polyclonal-antibody-ra22971","provider":"AFSBio Inc.","version":"1.0","type":"link"}