{"product_id":"cd206-rabbit-polyclonal-antibody-es8414","title":"CD206 Rabbit Polyclonal Antibody - ES8414","description":"\u003cp\u003eCD206 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES8414-50, ES8414-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: MRC1, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Macrophage mannose receptor 1-like protein 1, CD206\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human MRC1. AA range:341-390\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CD206\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD206 Polyclonal Antibody detects endogenous levels of CD206 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/20000. IF 1:100-300 Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Milk, Placenta, Testis,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 170kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Phagosome, Tuberculosis\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens\u003cbr\u003e\nMiscellaneous: CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates\u003cbr\u003e\nOnline Information: Macrophage mannose receptor,Similarity: Contains 1 fibronectin type-II domain\u003cbr\u003e\nSimilarity: Contains 1 ricin B-type lectin domain\u003cbr\u003e\nSimilarity: Contains 8 C-type lectin domains\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Endosome membrane, Single-pass type I membrane protein Cell membrane, Single-pass type I membrane protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: MRC1\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Macrophage mannose receptor 1\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 17533\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q61830\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313808363699,"sku":"ES8414-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313808396467,"sku":"ES8414-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/cd206-rabbit-polyclonal-antibody-es8414","provider":"AFSBio Inc.","version":"1.0","type":"link"}