{"product_id":"cd217-recombinant-protein-ncp0369","title":"CD217 Recombinant Protein - NCP0369","description":"\u003cp\u003eCD217 Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0369-500, NCP0369-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q96F46\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: MLRLLDHRALVCSQPGLNCt VKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVt VHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNIt VETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSAt VSCPEMPDTPEPIPDYMPLW\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: The IL-17 family of cytokines consists of IL-17A-F, and their receptors include IL-17RA-RE. IL-17 cytokines are produced by a variety of cell types including the Th17 subset of CD4+ T cells, as well as subsets of γδ T cells, NK cells, and NKT cells. IL-17A and IL-17F, the most well-studied of the IL-17 cytokines, contribute to fungal and bacterial immunity by inducing expression of proinflammatory cytokines, chemokines, and antimicrobial peptides. In addition, IL-17A contributes to the pathogenesis of several autoimmune disease. IL-17E promotes Th2 cell responses. The roles of IL-17B, IL-17C, and IL-17D are less clear, however these family members also appear to have the capacity to induce proinflammatory cytokines. IL-17 receptors have an extracellular domain, a transmembrane domain, and a SEFIR domain. They are believed to signal as homodimers, heterodimers, or multimers through their SEFIR domain by recruiting the SEFIR domain-containing adaptor Act1. Unlike most cytokines that signal through Jak\/STAT pathways, IL-17 signaling results in NF-κB activation.\u003cbr\u003e\nIL-17RA associates with IL-17RC to mediate signaling by homodimers and heterodimers of IL-17A and IL-17. IL-17RA is broadly expressed with highest expression in hematopoietic cells.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~37kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887072219315,"sku":"NCP0369-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887072252083,"sku":"NCP0369-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_e513ff4c-78e6-422e-a84a-fe0fdfe5e698.jpg?v=1702317535","url":"https:\/\/afsbio.com\/products\/cd217-recombinant-protein-ncp0369","provider":"AFSBio Inc.","version":"1.0","type":"link"}