{"product_id":"cd22-recombinant-protein-ncp0191","title":"CD22 Recombinant Protein - NCP0191","description":"\u003cp\u003eCD22 Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0191-500, NCP0191-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P20273\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: GATAGTAGCAAATGGGTGTTCGAACATCCGGAAACCTTATATGCCTGGGAAGGTGCATGCGTGTGGATTCCGTGTACCTATCGCGCACTGGATGGCGATCTGGAAAGCTTCATTCTGTTCCATAATCCGGAATATAATAAGAATACCAGCAAATTCGACGGCACCCGCCTGTATGAAAGCACCAAAGATGGTAAAGTTCCGAGTGAACAGAAACGTGTTCAGTTCCTGGGCGATAAAAATAAAAATTGCACCCTGAGCATTCATCCGGTGCATCTGAATGATAGCGGTCAGCTGGGCCTGCGCATGGAAAGTAAAACCGAAAAATGGATGGAACGTATTCATCTGAATGTTAGCGAACGTCCGTTCCCGCCGCATATTCAGCTGCCGCCGGAAATTCAGGAAAGTCAGGAAGTTACCCTGACCTGTCTGCTGAACTTCAGTTGCTATGGCTATCCGATTCAGCTGCAGTGGCTGCTGGAAGGCGTGCCGATGCGCCAGGCCGCTGTGACAAGCACCAGCCTGACCATTAAAAGTGTGTTCACCCGTAGTGAACTGAAATTCAGTCCGCAGTGGAGCCATCATGGTAAAATTGTGACCTGCCAGCTGCAGGATGCCGATGGCAAATTCCTGAGCAATGATACCGTTCAGCTGAATGTGAAACATACCCCGAAACTGGAAATTAAAGTGACCCCGAGTGATGCAATTGTTCGCGAAGGTGATAGTGTGACCATGACCTGTGAAGTTAGCAGCAGTAATCCGGAATACACCACCGTTAGCTGGCTGAAAGATGGCACCAGTCTGAAAAAACAGAATACCTTCACCCTGAATCTGCGCGAAGTGACCAAAGATCAGAGCGGTAAATATTGCTGTCAGGTTAGCAATGATGTGGGCCCGGGCCGTAGCGAAGAAGTGTTCCTGCAGGTGCAGTATGCACCGGAACCGAGTACCGTGCAGATTCTGCATAGCCCGGCCGTGGAAGGTAGCCAGGTTGAATTCCTGTGCATGAGCCTGGCAAATCCGCTGCCGACCAATTATACCTGGTATCATAATGGCAAAGAAATGCAGGGTCGCACCGAAGAAAAAGTGCATATTCCGAAAATTCTGCCGTGGCATGCAGGTACCTATAGTTGTGTGGCCGAAAATATTCTGGGTACCGGTCAGCGCGGTCCGGGTGCTGAACTGGATGTGCAGTATCCGCCGAAAAAAGTGACCACCGTTATTCAGAATCCGATGCCGATTCGTGAAGGCGATACCGTGACCCTGAGCTGTAATTATAATAGCAGCAATCCGAGCGTGACCCGCTATGAATGGAAACCGCATGGCGCCTGGGAAGAACCGAGTCTGGGTGTGCTGAAAATTCAGAATGTGGGCTGGGATAATACCACCATTGCATGTGCCGCATGCAATAGCTGGTGTAGCTGGGCCAGCCCGGTTGCACTGAATGTTCAGTATGCACCTCGTGATGTGCGTGTGCGTAAAATTAAACCGCTGAGCGAAATTCATAGTGGTAATAGTGTTAGTCTGCAGTGTGACTTCAGCAGTAGCCATCCGAAAGAAGTGCAGTTCTTCTGGGAAAAAAATGGTCGCCTGCTGGGCAAAGAAAGTCAGCTGAACTTCGATAGTATTAGCCCGGAAGATGCCGGTAGCTATAGTTGTTGGGTTAATAATAGCATTGGTCAGACCGCCAGTAAAGCATGGACCCTGGAAGTGCTGTATGCACCGCGTCGTCTGCGTGTGAGTATGAGTCCGGGTGATCAGGTTATGGAAGGTAAAAGTGCAACCCTGACCTGCGAAAGTGATGCAAATCCGCCGGTTAGTCATTATACCTGGTTCGATTGGAATAATCAGAGTCTGCCGTATCATAGTCAGAAACTGCGCCTGGAACCGGTTAAAGTGCAGCATAGCGGTGCATATTGGTGTCAGGGCACCAATAGTGTTGGTAAAGGCCGTAGCCCGCTGAGTACCCTGACCGTGTATTATAGCCCGGAAACCATTGGCCGTCGC\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD22 (also known as siglec-2) is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family of immunomodulatory receptors. CD22 can bind to its ligand α 2,6-linked sialic acid on different cells (trans interaction) as well as on the same cells (cis interaction). CD22 is predominantly expressed on B cells and functions as an inhibitory co-receptor for the B cell receptor (BCR). After BCR ligation, the tyrosine kinase Lyn is activated and phosphorylates two distal of the four ITIM motifs in the intracellular carboxy-terminal region of CD22, which then recruit tyrosine phosphatases, including SHP-1, to the plasma membrane, and in turn, they get tyrosine-phosphorylated and activated to damp the signaling pathways initiated by BCR ligation. CD22 has been actively pursued as a therapeutic target for autoimmune diseases. Due to almost exclusive expression on B cells, it is also actively pursued as a therapeutic target for multiple B cell malignancies.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~74kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887058325683,"sku":"NCP0191-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887058358451,"sku":"NCP0191-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_667e218d-f240-4b70-b878-45bc4b7b9d18.jpg?v=1702317198","url":"https:\/\/afsbio.com\/products\/cd22-recombinant-protein-ncp0191","provider":"AFSBio Inc.","version":"1.0","type":"link"}