{"product_id":"cd222-monoclonal-antibody-bt-mca4667","title":"CD222 Monoclonal Antibody - BT-MCA4667","description":"\u003cp\u003eCD222 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4667-50, BT-MCA4667-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Others\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CD222\u003c\/p\u003e\n\n\u003cp\u003eApplications: FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4F1G1\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CD222\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CD222 (AA: 160-311) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 274kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P11717\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: IGF2R, MPR1, MPRI, CIMPR, M6P-R, MPR300, CI-M6PR, MPR 300, M6P\/IGF2R\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3482\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238524969139,"sku":"BT-MCA4667-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238525001907,"sku":"BT-MCA4667-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_41f9cebb-b35d-49fa-8cc5-992a39ef781f.png?v=1769382214","url":"https:\/\/afsbio.com\/products\/cd222-monoclonal-antibody-bt-mca4667","provider":"AFSBio Inc.","version":"1.0","type":"link"}