{"product_id":"cd223-rat-monoclonal-antibody-mb65845","title":"CD223 Rat Monoclonal Antibody-MB65845","description":"\u003cp\u003eCD223 Rat Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers:MB65845-50, MB65845-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rat IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q61790\u003c\/p\u003e\n\n\u003cp\u003eHost: Rat\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF (1\/50 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Lymphocyte activation gene 3 (LAG-3, CD223) is an immune checkpoint control protein that negatively regulates T cells and immune responses. A CD4-like member of the Ig superfamily, LAG3 contains an extracellular IgV and three IgC domains, a transmembrane domain, and a short cytoplasmic region. LAG3 is primarily expressed by activated CD4+ T cells, CD8+ T cells, Tregs, and NK cells, where it's activated by MHC Class II molecules, its only known ligand. While it was initially shown to activate Treg cells, LAG3 can also inhibit CD8+ T cells. LAG3 is often co-expressed with PD-1 on the surface of tumor infiltrating lymphocytes, where the two proteins act independently to contribute to tumor-mediated immune suppression. Blockade of LAG3 is a promising strategy for neoplastic intervention.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The monoclonal antibody  was affinity-purified from Rat antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 57 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes mouse CD223\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: FDC; Lymphocyte activation gene 3 protein; LAG-3; Protein FDC; CD223\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Murine CD223-Ig fusion protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895054536883,"sku":"MB65845-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895054569651,"sku":"MB65845-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d554ad07-dc4d-4214-ad90-acc4307c6b22.jpg?v=1702573114","url":"https:\/\/afsbio.com\/products\/cd223-rat-monoclonal-antibody-mb65845","provider":"AFSBio Inc.","version":"1.0","type":"link"}