{"product_id":"cd274-monoclonal-antibody-bt-mca2951","title":"CD274 Monoclonal Antibody - BT-MCA2951","description":"\u003cp\u003eCD274 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2951-50, BT-MCA2951-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Immunology, Signal transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CD274\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6D9A2\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG2b\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CD274\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CD274 (AA: 24-153) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 33.3kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Q9NZQ7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: B7-H, B7H1, PDL1, PD-L1, PDCD1L1, PDCD1LG1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 29126\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238538993843,"sku":"BT-MCA2951-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238539026611,"sku":"BT-MCA2951-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_de85f07c-4a00-41b0-a6c8-0f7b0011696d.png?v=1769382359","url":"https:\/\/afsbio.com\/products\/cd274-monoclonal-antibody-bt-mca2951","provider":"AFSBio Inc.","version":"1.0","type":"link"}