{"product_id":"cd276-recombinant-protein-ncp0197","title":"CD276 Recombinant Protein - NCP0197","description":"\u003cp\u003eCD276 Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0197-500, NCP0197-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q5ZPR3\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: CTGGAAGTGCAGGTTCCGGAAGATCCGGTTGTTGCACTGGTTGGTACCGATGCAACCCTGTGTTGCAGCTTCAGTCCGGAACCGGGCTTCAGCCTGGCCCAGCTGAATCTGATCTGGCAGCTGACCGATACCAAACAGCTGGTTCATAGCTTCGCAGAAGGTCAGGATCAGGGCAGCGCATACGCTAATCGCACCGCCCTGTTCCCGGATCTGCTGGCACAGGGCAATGCCAGTCTGCGTCTGCAGCGCGTGCGCGTGGCCGATGAAGGCAGCTTCACCTGCTTCGTTAGCATTCGCGACTTCGGTAGTGCAGCAGTGAGCCTGCAGGTTGCCGCCCCGTATAGTAAACCGAGCATGACCCTGGAACCGAATAAAGATCTGCGTCCGGGCGATACCGTTACCATTACCTGCAGTAGTTATCAGGGTTATCCGGAAGCCGAAGTGTTCTGGCAGGATGGCCAGGGCGTTCCGCTGACCGGCAATGTTACCACCAGTCAGATGGCAAATGAACAGGGCCTGTTCGATGTTCATAGCATTCTGCGTGTGGTGCTGGGCGCAAATGGTACCTATAGTTGCCTGGTGCGTAATCCGGTGCTGCAGCAGGATGCACATAGCAGTGTGACCATTACCCCGCAGCGTAGTCCGACCGGCGCAGTTGAAGTGCAGGTGCCGGAAGATCCTGTGGTTGCCCTGGTTGGTACAGATGCAACCTTACGCTGCAGCTTCAGCCCGGAACCGGGCTTCAGTCTGGCCCAGTTAAATCTGATCTGGCAACTGACCGATACAAAACAGCTGGTGCATAGCTTCACCGAAGGTCGCGATCAGGGCTCAGCCTATGCCAATCGTACCGCCCTGTTCCCTGATCTGCTGGCGCAGGGCAATGCGAGTCTGCGTCTTCAGCGCGTGCGTGTGGCAGATGAAGGTAGCTTCACCTGCTTCGTGAGTATTCGCGACTTCGGCAGTGCAGCCGTTAGTCTGCAGGTGGCAGCACCGTATAGCAAACCGAGTATGACCCTGGAGCCGAATAAAGACCTGCGCCCGGGCGATACAGTGACCATTACATGCAGCAGTTATCGCGGCTATCCGGAAGCGGAAGTGTTCTGGCAAGATGGCCAGGGTGTGCCGCTGACCGGTAATGTTACCACAAGTCAGATGGCCAATGAACAGGGTCTGTTCGATGTGCATAGTGTTCTGCGTGTGGTTCTGGGCGCCAATGGTACCTACAGCTGCCTGGTGCGCAATCCGGTTCTGCAGCAGGACGCCCATGGTAGTGTTACCATTACAGGTCAGCCGATGACCTTCCCGCCGGAAGCC\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: B7 homolog 3 (B7-H3, CD276) is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. B7-H3 protein contains two extracellular Ig-like V-type domains and two IgG-like C2-type domains, a transmembrane domain, and a short intracellular domain. Early research examining the biological process of B7-H3 suggested that B7-H3 is a positive regulator of T cell response. Subsequent research studies indicated that B7-H3 is a negative regulator of T cell response, and that the protein inhibits T cell proliferation. One possibility is that B7-H3 interacts with two distinct sets of receptors, resulting in seemingly opposite biological outcomes. B7-H3 is expressed by antigen presenting cells, activated T cells, and a few normal tissues, including placenta and prostate. Expression of B7-H3 is seen in several cancer types, including prostate, breast, colon, lung, and gastric cancers, and in endothelial cells from tumor associated vasculature.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~48kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887058784435,"sku":"NCP0197-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887058817203,"sku":"NCP0197-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_a863a2e0-b65f-4542-9ec6-36a67ae84e76.jpg?v=1702317210","url":"https:\/\/afsbio.com\/products\/cd276-recombinant-protein-ncp0197","provider":"AFSBio Inc.","version":"1.0","type":"link"}