{"product_id":"cd279-monoclonal-antibody-mb65826","title":"CD279 Monoclonal Antibody -MB65826","description":"\u003cp\u003eCD279 Monoclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eCatalogue Numbers:MB65826-50, MB65826-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q15116\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF (1\/50 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003eBackground: The programmed cell death 1 protein (PD-1, PDCD1, CD279) is a member of the CD28 family of immunoreceptors that regulate T cell activation and immune responses. The PD-1 protein contains an extracellular Ig V domain, a transmembrane domain, and a cytoplasmic tail that includes an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). PD-1 is activated by the cell surface ligands PD-L1 and PD-L2. Upon activation, PD-1 ITIM and ITSM phosphorylation leads to the recruitment of the protein tyrosine phosphatases SHP-1 and SHP-2, which suppress TCR signaling . In addition to activated T cells, PD-1 is expressed in activated B cells and monocytes, although its function in these cell types has not been fully characterized. The PD-1 pathway plays an important role in immune tolerance; however, research studies show that cancer cells often adopt this pathway to escape immune surveillance. Consequently, blockade of PD-1 and its ligands is proving to be a sound strategy for neoplastic intervention.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The monoclonal antibody  was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 31 kDa\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes human CD279\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003cbr\u003e\nAlternative Name: PD1; Programmed cell death protein 1; Protein PD-1; hPD-1; CD279\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Native purified human CD279\u003c\/p\u003e \n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42895052636339,"sku":"MB65826-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42895052669107,"sku":"MB65826-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d5d4da88-3351-4927-83a3-3b6bb2d42b8c.jpg?v=1702573084","url":"https:\/\/afsbio.com\/products\/cd279-monoclonal-antibody-mb65826","provider":"AFSBio Inc.","version":"1.0","type":"link"}