{"product_id":"cd28-polyclonal-antibody-bs65740","title":"CD28 Polyclonal Antibody-BS65740","description":"\u003cp\u003eCD28 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS65740-50, BS65740-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P31041\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eCD28 Polyclonal Antibody-BS65740\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB,\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB=1:500-2000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Human CD28 antigen is a 44 kDa disulfide linked homodimeric T cell specific surface glycoprotein. It is a cell adhesion molecule of the immunoglobulin superfamily which is constitutively expressed on most peripheral blood T lymphocytes (approximately 95% of CD4+ cells and 50% of CD8+ cells). Mature thymocytes exhibit higher levels of CD28 than the immature cells. Activation of T cells results in enhanced CD28 expression. T cell activation requires two combined signals provided by antigen presenting cells. The first is mediated via the T cell receptor following its interaction with antigenic peptide MHC complexes, and the second is delivered by accessory or costimulating molecules through their counter receptors on T lymphocytes. CD28 bears structural homology to CTLA 4 which is expressed at very low levels on the surface of CD4+ and CD8+ peripheral blood cells only following activation. CD28 is the natural receptor for the B7\/BB 1 ligand (CD80) a 55-60 kDa glycoprotein which is expressed on activated B lymphocytes, on dendritic cells and on interferon gamma treated monocytes. The binding of B7 1\/BB 1 molecules to CD28 is involved in T lymphocyte activation and in the initiation and maintenance of chronic inflammation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: affinity purified by Protein A\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD28 Polyclonal Antibody detects endogenous levels of CD28 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 50 kD，44kD\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Primary: Anti-CD28 at 1\/1000 dilution, Primary: Anti-CD28 at 1\/1000 dilution\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: CD 28; CD28 antigen; CD28 molecule; MGC138290; T cell antigen CD28; T cell specific surface glycoprotein; T cell specific surface glycoprotein CD28; Tp44.\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH conjugated synthetic peptide derived from mouse CD28:1-120\/218\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42962763743411,"sku":"BS65740-50","price":342.59,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42962763776179,"sku":"BS65740-100","price":589.65,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_d59e515a-b1a8-40bb-8647-c0f2150938b4.jpg?v=1705318811","url":"https:\/\/afsbio.com\/products\/cd28-polyclonal-antibody-bs65740","provider":"AFSBio Inc.","version":"1.0","type":"link"}