{"product_id":"cd30-monoclonal-antibody-mb66955","title":"CD30 Monoclonal Antibody - MB66955","description":"\u003cp\u003eCD30 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: MB66955-50, MB66955-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: TNFRSF8\/CD30 is a type-I transmembrane glycoprotein that is a member of the TNFR superfamily. CD30 is synthesized as a precursor protein that undergoes extensive post-translational modification before becoming embedded in the plasma membrane as a 120-kDa transmembrane protein . The expression of CD30 is upregμlated in activated T cells and may trigger costimμlatory signaling pathways upon its engagement . While its expression is normally restricted to subsets of activated T cells and B cells, CD30 expression is robustly upregμlated in hematologic malignancies, such as Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), and adμlt T-cell leukemia, thus making it an attractive target for therapeutic intervention . Research studies have suggested that in certain disease contexts, CD30 recruits TRAF2 and TRAF5 adaptor proteins to drive NF-kappa B activation, aberrant cell growth, and cytokine production . CD30 signaling is also regμlated by TACE-dependent proteolytic cleavage of its ectodomain, which resμlts in reduced CD30L-dependent activation of CD30+ cells .\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD30, D1S166E, Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD30\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human CD30. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB (1\/500 - 1\/1000)\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of CD30 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 95 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: PI3K AKT signaling.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P28908\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Supplied in crude ascites with 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946157727923,"sku":"MB66955-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946157760691,"sku":"MB66955-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/cd30-monoclonal-antibody-mb66955","provider":"AFSBio Inc.","version":"1.0","type":"link"}