{"product_id":"cd300a-recombinant-protein-ncp0387","title":"CD300A Recombinant Protein - NCP0387","description":"\u003cp\u003eCD300A Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0387-500, NCP0387-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9UGN4\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\n\n\u003cp\u003eNdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD300a is an inhibitory receptor in the Ig superfamily, a type I transmembrane protein containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on its cytoplasmic tail. Human CD300a (CMRF-35H, IRp60) and mouse CD300a (CLM-8, LMIR-1, MAIR-I) are functional orthologs, expressed by monocytes, granulocytes, mast cells, and subsets of B cells. Human, but not mouse, CD300a is also expressed by unstimulated NK cells and subsets of T cells. Phosphorylated ITIMs are able to recruit different phosphatases, such as SHP-1 and SHP-2, leading to inhibition of cell activation.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~23kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887073956019,"sku":"NCP0387-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887073988787,"sku":"NCP0387-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_b98d202d-3e5d-4f94-9c04-502090db193a.jpg?v=1702317573","url":"https:\/\/afsbio.com\/products\/cd300a-recombinant-protein-ncp0387","provider":"AFSBio Inc.","version":"1.0","type":"link"}