{"product_id":"cd31-polyclonal-antibody-bs66145","title":"CD31 Polyclonal Antibody - BS66145","description":"\u003cp\u003eCD31 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS66145-50, BS66145-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: nduces susceptibility to atherosclerosis (By similarity). Cell adhesion molecμle which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repμlsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repμlsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engμlfment). Isoform Delta15 is unable to protect against apoptosis. Modμlates BDKRB2 activation. Regμlates bradykinin- and hyperosmotic shock-induced ERK1\/2 activation in human umbilical cord vein cells (HUVEC).\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IP\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: platelet endothelial cell adhesion molecμle precursor-1, PECAM-1, PECAM1, Adhesion molecμle, CD31 antigen, CD31 EndoCAM, Endocam, FLJ34100, FLJ58394, GPIIA, Pecam 1, PECA1_HUMAN, PECAM 1 CD31 EndoCAM, PECA1, Pecam1, Platelet endothelial cell adhesion molecμle, Platelet\/endothelial cell adhesion molecμle 1, Adhesion molecμle, Platelet\/endothelial cell adhesion molecμle\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 630-738 of CD31\/PECAM1 (NP_000433.4).\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:100-1:500\u003cbr\u003e\nIP: 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD31 polyclonal antibody detects endogenous levels of CD31 protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 130 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P16284\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45938577506483,"sku":"BS66145-50","price":349.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45938577539251,"sku":"BS66145-100","price":582.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_7d54f7f7-895a-4faa-805b-93c7ca9b170c.jpg?v=1788296274","url":"https:\/\/afsbio.com\/products\/cd31-polyclonal-antibody-bs66145","provider":"AFSBio Inc.","version":"1.0","type":"link"}