{"product_id":"cd319-recombinant-protein-ncp0319","title":"CD319 Recombinant Protein - NCP0319","description":"\u003cp\u003eCD319 Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0319-500, NCP0319-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q9NQ25\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: SGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVD\u003cbr\u003e\nFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKN\u003cbr\u003e\nGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVS\u003cbr\u003e\nRNFSSPILARKLCEGAADDPDSSM\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: CRACC\/SLAMF7\/CD319 (also known as CS1) is a member of the signaling lymphocytic activation molecule (SLAM) family. It is a single-pass type l transmembrane glycoprotein expressed on NK cells, subsets of mature dendritic cells, activated B and T lymphocytes, but not in promyelocytic B or T cell lines. Expression of this protein has been detected in the spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea. Homophilic interactions of CRACC\/SLAMF7\/CD319 modulate the activity and differentiation of immune cells. CRACC\/SLAMF7\/CD319 may function as an inhibitory or activating receptor in immune cells depending on cellular context and availability of adapter proteins, SH2D1A\/SAP and\/or SH2D1B\/EAT-2. In the presence of SH2D1B\/EAT-2, CRACC\/SLAMF7\/CD319 activates NK cells and B cells. T cells lack SH2D1B\/EAT-2 expression, and therefore CRACC\/SLAMF7\/CD319 acts as an inhibitory receptor. In LPS-activated monocytes, CRACC\/SLAMF7\/CD319 negatively regulates production of proinflammatory cytokines. CRACC\/SLAMF7\/CD319 is upregulated in multiple myeloma and is implicated in the uncontrolled proliferation of these cells, and thus has become the target for therapeutic intervention. Seven isoforms of CRACC\/SLAMF7\/CD319 produced by alternative splicing have been identified.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~25kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887067730099,"sku":"NCP0319-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887067762867,"sku":"NCP0319-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_f9df892d-f339-4ecc-a52d-4297ee07bf63.jpg?v=1702317450","url":"https:\/\/afsbio.com\/products\/cd319-recombinant-protein-ncp0319","provider":"AFSBio Inc.","version":"1.0","type":"link"}