{"product_id":"cd32-c-polyclonal-antibody-ra23045","title":"CD32-C Polyclonal Antibody - RA23045","description":"\u003cp\u003eCD32-C Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA23045-50, RA23045-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: caution:Has sometimes been attributed to correspond to FcR-IIB.,caution:Has sometimes been attributed to correspond to FcR-IIC.,disease:A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t (1;22) (q22;q11) . The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.,domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) . This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,domain:Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM) . These motifs are involved in triggering cell activation upon receptors aggregation.,function:Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.,function:Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D\/SHIP1.,tissue specificity:Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells) . Not detected in natural killer cells.,tissue specificity:Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.,\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: FCGR2C; CD32; FCG2; IGFR2; Low affinity immunoglobulin gamma Fc region receptor II-c; IgG Fc receptor II-c; CDw32; Fc-gamma RII-c; Fc-gamma-RIIc; FcRII-c; CD antigen CD32\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Rat; Mouse\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 9103\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 35\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P31995\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121185448115,"sku":"RA23045-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121185480883,"sku":"RA23045-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_212e4dff-0514-4444-8a2f-ca61ac712e4a.png?v=1773344953","url":"https:\/\/afsbio.com\/products\/cd32-c-polyclonal-antibody-ra23045","provider":"AFSBio Inc.","version":"1.0","type":"link"}