{"product_id":"cd33-monoclonal-antibody-bt-mca4839","title":"CD33 Monoclonal Antibody - BT-MCA4839","description":"\u003cp\u003eCD33 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA4839-50, BT-MCA4839-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD)\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CD33\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 2C6B7\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CD33\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 39.8kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P20138\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: p67, SIGLEC3, SIGLEC-3\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 945\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238553215155,"sku":"BT-MCA4839-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238553247923,"sku":"BT-MCA4839-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_dae48551-019b-4b47-885d-65d03d5bb50b.png?v=1769382494","url":"https:\/\/afsbio.com\/products\/cd33-monoclonal-antibody-bt-mca4839","provider":"AFSBio Inc.","version":"1.0","type":"link"}