{"product_id":"cd4-monoclonal-antibody-mb65780","title":"CD4 Monoclonal Antibody-MB65780","description":"\u003cp\u003eCD4 Monoclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eCatalogue Numbers: MB65780-50, MB65780-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG2a kappa. Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P01730\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF (1\/50 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The monoclonal antibody  was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes human CD4\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD4 Antibody, followed by anti-mouse IgG PE.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 51 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: T-cell surface glycoprotein CD4; T-cell surface antigen T4\/Leu-3; CD antigen CD4\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Native purified human CD4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908735144115,"sku":"MB65780-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908735176883,"sku":"MB65780-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1d03f4ca-7941-48fa-9f1e-27ee6b1c68c2.jpg?v=1703006444","url":"https:\/\/afsbio.com\/products\/cd4-monoclonal-antibody-mb65780","provider":"AFSBio Inc.","version":"1.0","type":"link"}