{"product_id":"cd4-recombinant-protein-ncp0207","title":"CD4 Recombinant Protein - NCP0207","description":"\u003cp\u003eCD4 Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0207-500, NCP0207-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P01730\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: AAGAAGGTGGTTCTGGGCAAAAAAGGTGATACCGTGGAACTGACCTGTACCGCAAGTCAGAAAAAAAGTATTCAGTTCCATTGGAAAAACAGCAATCAGATTAAAATCCTGGGTAATCAGGGTAGCTTCCTGACCAAAGGTCCGAGCAAACTGAATGATCGCGCCGATAGCCGTCGTAGTCTGTGGGATCAGGGTAACTTCCCGCTGATTATTAAAAATCTGAAAATCGAAGACAGCGATACCTATATCTGTGAAGTGGAAGATCAGAAAGAAGAAGTGCAGCTGCTGGTGTTCGGTCTGACCGCCAATAGTGATACCCATCTGCTGCAGGGTCAGAGCCTGACCCTGACCCTGGAAAGCCCGCCGGGTAGCAGCCCGAGTGTTCAGTGTCGTAGTCCGCGCGGCAAAAATATTCAGGGTGGCAAAACCTTAAGTGTTAGCCAGCTGGAACTGCAGGATAGCGGCACCTGGACCTGTACCGTTCTGCAGAATCAGAAAAAAGTTGAATTCAAAATCGACATCGTGGTTCTGGCATTCCAGAAAGCCAGCAGCATTGTGTATAAAAAAGAAGGCGAACAGGTGGAATTCAGCTTCCCGCTGGCCTTCACCGTGGAAAAACTGACCGGCAGCGGTGAACTGTGGTGGCAGGCCGAACGCGCCAGCAGCAGTAAAAGTTGGATTACCTTCGATCTGAAAAATAAAGAAGTGAGCGTTAAACGTGTTACCCAGGATCCGAAACTGCAGATGGGTAAAAAACTGCCGCTGCATCTGACCCTGCCGCAGGCACTGCCGCAGTATGCCGGCAGTGGTAATCTGACCCTGGCCCTGGAAGCCAAAACCGGCAAACTGCATCAGGAAGTTAATCTGGTTGTGATGCGTGCAACCCAGCTGCAGAAAAATCTGACCTGCGAAGTGTGGGGCCCGACCAGCCCGAAACTGATGCTGAGCCTGAAACTGGAAAATAAAGAAGCCAAAGTGAGTAAACGTGAAAAAGCAGTGTGGGTTCTGAATCCGGAAGCAGGCATGTGGCAGTGTCTGCTGAGCGATAGCGGTCAGGTTCTGCTGGAAAGCAATATTAAAGTTCTGCCGACCTGGAGCACCCCGGTTCAGCCG\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cluster of Differentiation 4 (CD4) is a glycoprotein composed of an amino-terminal extracellular domain (four domains: D1-D4 with Ig-like structures), a transmembrane part, and a short cytoplasmic tail. CD4 is expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells, and plays an important role in the development and activation of T cells. On T cells, CD4 is the co-receptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the D1 domain of CD4 interacts with the β2-domain of the MHC class II molecule. CD4 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and recruits the tyrosine kinase Lck, which is essential for T cell activation.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~45kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887059570867,"sku":"NCP0207-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887059603635,"sku":"NCP0207-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_1cef132a-e420-40ae-b716-1f947c7695ab.jpg?v=1702317232","url":"https:\/\/afsbio.com\/products\/cd4-recombinant-protein-ncp0207","provider":"AFSBio Inc.","version":"1.0","type":"link"}