{"product_id":"cd40-monoclonal-antibody-bt-mca2010","title":"CD40 Monoclonal Antibody - BT-MCA2010","description":"\u003cp\u003eCD40 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA2010-50, BT-MCA2010-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CD40\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 4E4C6\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CD40\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CD40 (AA: extra(21-193)) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 30.6kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P25942\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: p50, Bp50, CDW40, TNFRSF5\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 958\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238397534387,"sku":"BT-MCA2010-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238397567155,"sku":"BT-MCA2010-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_69cdc84c-0692-4194-b6bb-8b8829b3d778.png?v=1769379940","url":"https:\/\/afsbio.com\/products\/cd40-monoclonal-antibody-bt-mca2010","provider":"AFSBio Inc.","version":"1.0","type":"link"}