{"product_id":"cd6-recombinant-protein-ncp0218","title":"CD6 Recombinant Protein - NCP0218","description":"\u003cp\u003eCD6 Recombinant Protein\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0218-500, NCP0218-1000\u003c\/p\u003e\n\n\u003cp\u003eSizes: 500ug, 1mg\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P30203\u003c\/p\u003e\n\n\u003cp\u003eHost: E.coli\u003c\/p\u003e\n\n\u003cp\u003eTag: His-tag\u003c\/p\u003e\n\n\u003cp\u003eAA Sequence: CATCCGAGTCCGGCACCGCCTGATCAGCTGAATACCAGCAGCGCAGAAAGTGAACTGTGGGAACCGGGTGAACGTCTGCCGGTGCGCCTGACCAATGGCAGCAGCAGTTGCAGCGGCACCGTGGAAGTGCGCCTGGAAGCAAGTTGGGAACCGGCATGCGGTGCCCTGTGGGATAGCCGTGCAGCCGAAGCCGTGTGCCGCGCACTGGGTTGTGGCGGTGCAGAAGCCGCCAGCCAGCTGGCACCGCCTACCCCTGAACTGCCGCCGCCTCCTGCCGCTGGTAATACCAGCGTTGCAGCAAATGCAACCCTGGCAGGCGCACCGGCACTGCTGTGCAGTGGCGCAGAATGGCGTCTGTGCGAAGTTGTTGAACATGCATGTCGCAGTGATGGTCGCCGTGCCCGCGTTACCTGTGCCGAAAATCGTGCCCTGCGTCTGGTGGATGGCGGTGGCGCATGCGCAGGTCGTGTTGAAATGCTGGAACATGGCGAATGGGGCAGTGTGTGTGATGATACCTGGGATCTGGAAGATGCACATGTTGTGTGTCGCCAGCTGGGCTGTGGCTGGGCCGTGCAAGCCCTGCCTGGTCTGCACTTCACCCCGGGTCGTGGCCCGATTCATCGCGATCAGGTTAATTGCAGCGGTGCAGAAGCATATCTGTGGGATTGTCCGGGTCTGCCGGGCCAGCATTATTGTGGCCATAAAGAAGATGCAGGTGCCGTGTGCAGTGAACATCAGAGCTGGCGTCTGACCGGTGGTGCCGATCGCTGCGAAGGCCAGGTTGAAGTTCACTTCCGCGGCGTGTGGAATACCGTGTGCGATAGCGAATGGTATCCGAGCGAAGCCAAAGTGCTGTGCCAGAGTCTGGGTTGCGGTACCGCCGTGGAACGTCCGAAAGGTCTGCCGCATAGTCTGAGTGGTCGCATGTATTATAGCTGTAATGGTGAAGAACTGACCCTGAGCAATTGTAGCTGGCGCTTCAATAATAGTAATCTGTGCAGCCAGAGTCTGGCCGCACGCGTTCTGTGCAGCGCCAGTCGCAGCCTGCATAATCTGAGTACCCCGGAAGTTCCGGCCAGTGTTCAGACCGTGACCATTGAAAGTAGTGTGACCGTTAAAATTGAAAATAAGGAAAGCCGCGAACTGATGCTG\u003c\/p\u003e\n\n\u003cp\u003eRestriction Sites: NdeI-XhoI\u003c\/p\u003e\n\n\u003cp\u003eBackground: T cell differentiation antigen CD6 is a cell adhesion molecule expressed on immature thymocytes and mature T cells, and has also been detected on a subset of B cells and NK cells within the immune system. CD6 mediates cell-cell interactions through it’s binding partner CD166\/ALCAM, and contributes to the formation and maturation of the immunological synapse. CD6 functions as a co-stimulatory receptor, promoting T cell activation and proliferation through the TCR\/CD3 complex signaling cascade. Studies have shown CD6 can be glycosylated, hyperphosphorylated on serine and threonine residues, and phosphorylated on tyrosine residues, each of which can differentially effect the function and signaling of this molecule. CD6 also functions as a calcium-dependent pattern receptor that binds and aggregates Gram-positive and Gram-negative bacteria. In response to lipopolysaccharide, CD6 mediates activation of the inflammatory response and secretion of pro-inflammatory cytokines.\u003c\/p\u003e\n\n\u003cp\u003eSoluble: PBS, 4M Urea, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eExpression Vector: pet-22b(+)\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: ~44kDa\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"500ug","offer_id":42887060521139,"sku":"NCP0218-500","price":1050.83,"currency_code":"CAD","in_stock":true},{"title":"1mg","offer_id":42887060553907,"sku":"NCP0218-1000","price":1857.89,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_3f4459f2-89cc-47ed-a3f9-7c61fa45f47e.jpg?v=1702317256","url":"https:\/\/afsbio.com\/products\/cd6-recombinant-protein-ncp0218","provider":"AFSBio Inc.","version":"1.0","type":"link"}