{"product_id":"cd8-monoclonal-antibody-mb65804","title":"CD8 Monoclonal Antibody-MB65804","description":"\u003cp\u003eCD8 Monoclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eCatalogue Numbers: MB65804-50, MB65804-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eProduct: Mouse IgG1. Liquid in PBS, pH 7.3, and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: P01732; P10966\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF, FC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: IF (1\/50 - 1\/200)\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The monoclonal antibody  was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes human CD8\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Flow cytometric analysis of human peripheral blood lymphocytes using Anti-CD8 Antibody, followed by anti-mouse IgG PE.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 25 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: MAL; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8\/Leu-2; CD antigen CD8a; CD8B1; T-cell surface glycoprotein CD8 beta chain; CD antigen CD8b\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Native purified human CD8.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42908739043507,"sku":"MB65804-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42908739076275,"sku":"MB65804-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_51e9a83f-2a82-4c11-946c-ca63b1433459.jpg?v=1703006490","url":"https:\/\/afsbio.com\/products\/cd8-monoclonal-antibody-mb65804","provider":"AFSBio Inc.","version":"1.0","type":"link"}