{"product_id":"cd8a-polyclonal-antibody-ncp0234p","title":"CD8A  Polyclonal Antibody - NCP0234P","description":"\u003cp\u003eCD8A  Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: NCP0234P-50, NCP0234P-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: Integral membrane glycoprotein that plays an essential role in the immune response and serves mμltiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecμle:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellμlar proteins. Interacts simμltaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellμlar signaling pathways by phosphorylating various substratesμltimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of mμltiple target cells. CD8A homodimer molecμles also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Rat, Mouse\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8\/Leu-2, CD8a, CD8A, MAL\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human CD8A.\u003c\/p\u003e\n\n\u003cp\u003eDilution: IF: 1:100~1:500\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CD8A polyclonal antibody detects endogenous levels of CD8A protein.\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P01732\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45936699539635,"sku":"NCP0234P-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45936699572403,"sku":"NCP0234P-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image.jpg?v=1788296056","url":"https:\/\/afsbio.com\/products\/cd8a-polyclonal-antibody-ncp0234p","provider":"AFSBio Inc.","version":"1.0","type":"link"}