{"product_id":"cdc23-rabbit-polyclonal-antibody-es1925","title":"Cdc23 Rabbit Polyclonal Antibody - ES1925","description":"\u003cp\u003eCdc23 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1925-50, ES1925-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2\/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Monkey\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CDC23, ANAPC8, Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, APC8, Cyclosome subunit 8\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human APC8. AA range:251-300\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: Cdc23\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Cdc23 Polyclonal Antibody detects endogenous levels of Cdc23 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Bone marrow, Brain, Duodenum, Epithelium, Pancreas, Placenta,\u003c\/p\u003e \n\n\u003cp\u003eObserved Band (KD): 69kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, Progesterone-mediated oocyte maturation, Human T-cell leukemia virus 1 infection\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Component of the anaphase promoting complex\/cyclosome (APC\/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle\u003cbr\u003e\nPathway: Protein modification, protein ubiquitination\u003cbr\u003e\nPTM: Phosphorylated. Phosphorylation on Thr-556 occurs specifically during mitosis\u003cbr\u003e\nSimilarity: Belongs to the APC8\/CDC23 family\u003cbr\u003e\nSimilarity: Contains 9 TPR repeats\u003cbr\u003e\nSubunit: The APC\/C is composed of at least 11 subunits\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: intracellular, nucleoplasm, anaphase-promoting complex, cytosol,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CDC23\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Cell division cycle protein 23 homolog\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 52563\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q8BGZ4\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315877302451,"sku":"ES1925-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315877335219,"sku":"ES1925-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/cdc23-rabbit-polyclonal-antibody-es1925","provider":"AFSBio Inc.","version":"1.0","type":"link"}