{"product_id":"cdc5l-polyclonal-antibody-bs90276","title":"CDC5L Polyclonal Antibody-BS90276","description":"\u003cp\u003eCDC5L Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS90276-50, BS90276-100\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q99459(Human) Q6A068(Mouse) O08837(Rat)\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ICC\/IF, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB:1:1,000\u003cbr\u003e\nICC:1:50-1:200\u003cbr\u003e\nIHC:1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cdc5L (Cell division cycle 5-like protein, Pombe Cdc5-related protein) is a DNA-binding protein encoded by the human gene CDC5L. Cdc5L contains 2 HTH myb-type DNA-binding domains and may shuttle between cytoplasm and nucleus. It is involved in cell cycle control and may act as a transcription activator. CDC5L is a spliceosomal protein that is highly conserved across species. It is a member of a protein group that comprise the core of spliceosomal complexes and are essential for pre-mRNA splicing. Cdc5L is involved in the second catalytic step of pre-mRNA splicing, which involves cleavage at the 3' splice site and the ligation of the exons. This process releases the intact intron lariat. A chromosomal aberration involving Cdc5L is found in multicystic renal dysplasia. This aberration is caused by a translocation with USF-2.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: ProA affinity purified\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CDC5L polyclonal antibody detects endogenous levels of CDC5L protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: 92\/100 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of CDC5L on different lysates using anti-CDC5L antibody at 1\/1,000 dilution. \u003cbr\u003e\n Positive control:\u003cbr\u003e\n Lane 1: Hela\u003cbr\u003e\n Lane 2: Jurkat, ICC staining CDC5L in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100\/PBS.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cdc5-like protein, CDC5L, CDC5, CDC5 cell division cycle 5-like (S. pombe), Cdc5 related protein, CDC5-LIKE, Cdc5-like protein, Cdc5l, CDC5L, CEF1, Cell division cycle 5 S. pombe homolog of, Cell division cycle 5-like protein, dJ319D22.1, KIAA0432, PCDC5RP, Pombe Cdc5 related protein, Pombe Cdc5-related protein,\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: recombinant protein\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42979798319283,"sku":"BS90276-50","price":424.94,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42979798352051,"sku":"BS90276-100","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_6398e4ec-60f1-46ea-b7d1-25e17fffa006.jpg?v=1705752722","url":"https:\/\/afsbio.com\/products\/cdc5l-polyclonal-antibody-bs90276","provider":"AFSBio Inc.","version":"1.0","type":"link"}