{"product_id":"cdc6-phospho-s54-polyclonal-antibody-bs4036","title":"Cdc6 (phospho-S54) Polyclonal Antibody-BS4036","description":"\u003cp\u003eCdc6 (phospho-S54) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS4036-50, BS4036-100\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q99741\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eCdc6 (phospho-S54) Polyclonal Antibody-BS4036\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4\/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: p-Cdc6 (S54) polyclonal antibody detects endogenous levels of Cdc6 only when phosphorylated at Ser54.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 62 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of p-Cdc6 (S54) polyclonal antibody at 1:500 dilution\u003cbr\u003e\n Lane 1: Hela cell lysate treated with serum starvation\u003cbr\u003e\n Lane 2: Raw264.7 cell lysate treated with serum starvation\u003cbr\u003e\n Lane 3: H9C2 cell lysate treated with serum starvation, Immunohistochemistry (IHC) analysis of p-Cdc6 (S54) pAb in paraffin-embedded human lung carcinoma tissue.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6; CDC6; CDC18L; p62 Cdc6\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic phosphopeptide derived from human Cdc6 around the phosphorylation site of Serine 54.\u003c\/p\u003e\n\n\u003cp\u003eModification: Phosphorylation\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42957294731443,"sku":"BS4036-50","price":276.71,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42957294764211,"sku":"BS4036-100","price":490.83,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_933f0776-9e0e-4d64-bd7b-c4545d6fc43c.jpg?v=1705144487","url":"https:\/\/afsbio.com\/products\/cdc6-phospho-s54-polyclonal-antibody-bs4036","provider":"AFSBio Inc.","version":"1.0","type":"link"}