{"product_id":"cdca7-rabbit-polyclonal-antibody-es7716","title":"CdcA7 Rabbit Polyclonal Antibody - ES7716","description":"\u003cp\u003eCdcA7 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES7716-50, ES7716-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: cell division cycle associated 7(CDCA7) Homo sapiens This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CDCA7, JPO1, Cell division cycle-associated protein 7, Protein JPO1\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CDCA7. AA range:141-190\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CdcA7\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CdcA7 Polyclonal Antibody detects endogenous levels of CdcA7 protein.\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Ubiquitous with higher level in thymus and small intestine, Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis,\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 43kD\u003c\/p\u003e\n\n\u003cp\u003eFunction: Function: Participates in MYC-mediated cell transformation, induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator\u003cbr\u003e\nInduction: Activated by MYC and possibly E2F1\u003cbr\u003e\nMiscellaneous: CDCA7 expression is correlated with MYC expression in lymphoblastoid, lymphoma and breast cancer cell lines\u003cbr\u003e\nTissue Specificity: Ubiquitous with higher level in thymus and small intestine. Overexpressed in a large number of tumors, in blood from patients with acute myelogenous leukemia (AML) and in chronic myelogenous leukemia (CML) blast crisis\u003c\/p\u003e\n\n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm Predominantly nuclear with some expression also seen in the cytoplasm Predominantly cytoplasmic when phosphorylated at Thr-163\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: CDCA7\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: Cell division cycle-associated protein 7\u003c\/p\u003e\n\n\u003cp\u003eMouse Gene ID: 66953\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q9D0M2\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 311742\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q4KM91\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46313743777971,"sku":"ES7716-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46313743810739,"sku":"ES7716-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies_d75295e2-ffc1-4e0f-a3e7-87715c8983a9.jpg?v=1793190507","url":"https:\/\/afsbio.com\/products\/cdca7-rabbit-polyclonal-antibody-es7716","provider":"AFSBio Inc.","version":"1.0","type":"link"}