{"product_id":"cdh1-monoclonal-antibody-bt-mca3115","title":"CDH1 Monoclonal Antibody - BT-MCA3115","description":"\u003cp\u003eCDH1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3115-50, BT-MCA3115-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and\/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction, Cancer, Developmental biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CDH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 6G2B3\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CDH1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CDH1 (AA:extra(155-354)) expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Purified antibody in PBS with 0.05% sodium azide\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 97.5kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P12830\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: UVO, CDHE, ECAD, LCAM, Arc-1, BCDS1, CD324\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 999\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238395142323,"sku":"BT-MCA3115-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238395175091,"sku":"BT-MCA3115-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_40c659af-6125-4290-8b53-d6052ac8b77a.png?v=1769379885","url":"https:\/\/afsbio.com\/products\/cdh1-monoclonal-antibody-bt-mca3115","provider":"AFSBio Inc.","version":"1.0","type":"link"}