{"product_id":"cdh1-monoclonal-antibody-bt-mca3470","title":"CDH1 Monoclonal Antibody - BT-MCA3470","description":"\u003cp\u003eCDH1 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: BT-MCA3470-50, BT-MCA3470-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin\/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal transduction, Cancer, Developmental biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CDH1\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, FCM\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Monkey\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone ID: 7H12\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eIsotype: Mouse IgG1\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CDH1\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.\u003c\/p\u003e\n\n\u003cp\u003eStorage: 4°C|-20°C for long term storage\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Ascitic fluid containing 0.03% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 135kDa\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: P12830\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: UVO, CDHE, ECAD, LCAM, Arc-1, CD324, CDH1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 999\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"50μL","offer_id":45238612558003,"sku":"BT-MCA3470-50","price":308.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45238612590771,"sku":"BT-MCA3470-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f0d40582-b046-4972-92ef-081934295f3d.png?v=1769383066","url":"https:\/\/afsbio.com\/products\/cdh1-monoclonal-antibody-bt-mca3470","provider":"AFSBio Inc.","version":"1.0","type":"link"}