{"product_id":"cdk4-polyclonal-antibody-ra20553","title":"Cdk4 Polyclonal Antibody - RA20553","description":"\u003cp\u003eCdk4 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RA20553-50, RA20553-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: cyclin dependent kinase 4 (CDK4) Homo sapiens The protein encoded by this gene is a member of the Ser\/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16 (INK4a) . This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb) . Mutations in this gene as well as in its related proteins including D-type cyclins, p16 (INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008],\u003c\/p\u003e\n\n\u003cp\u003eCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eStorage Instructions: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eRecommended dilutions: IF: 1:50-200 Western Blot: 1\/500 - 1\/2000. IHC-p: 1:100-300 ELISA: 1\/20000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Names: CDK4; Cyclin-dependent kinase 4; Cell division protein kinase 4; PSK-J3\u003c\/p\u003e\n\n\u003cp\u003eApplications: IF\/ICC; WB; IHC-p; ELISA\u003c\/p\u003e\n\n\u003cp\u003eSpecies Cross-Reactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eGeneID (Human): 1019\u003c\/p\u003e\n\n\u003cp\u003eProtein MW (KDa): 35\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P11802\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45120678396083,"sku":"RA20553-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45120678428851,"sku":"RA20553-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_804a6d0c-7f20-44a2-b5b0-bc5ead7c5b20.png?v=1773369343","url":"https:\/\/afsbio.com\/products\/cdk4-polyclonal-antibody-ra20553","provider":"AFSBio Inc.","version":"1.0","type":"link"}