{"product_id":"cdk8-polyclonal-antibody-ra23199","title":"Cdk8 Polyclonal Antibody - RA23199","description":"Cdk8 Polyclonal Antibody\n\nSizes: 50μL, 100μL\n\nCatalogue Numbers: RA23199-50, RA23199-100\n\nCitations, Manuals and MSDS Available upon request.\n\nBackground: cyclin dependent kinase 8 (CDK8) Homo sapiens The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7\/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008],\n\nCondition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\n\nStorage Instructions: -20°C\/1 year\n\nRecommended dilutions: Western Blot: 1\/500 - 1\/2000. Immunohistochemistry: 1\/100 - 1\/300. ELISA: 1\/10000. Not yet tested in other applications.\n\nAlternative Names: CDK8; Cyclin-dependent kinase 8; Cell division protein kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; Protein kinase K35\n\nApplications: WB; IHC-p; IF (paraffin section) ; ELISA\n\nSpecies Cross-Reactivity: Human; Mouse\n\nGeneID (Human): 1024\n\nProtein MW (KDa): 53\n\nSWISS: P49336\n\nSource: Rabbit\n\nResearch Use Only","brand":"Reed Bio","offers":[{"title":"50μL","offer_id":45121193967795,"sku":"RA23199-50","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45121194000563,"sku":"RA23199-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_c163ca73-7ba6-4208-8930-34345c21b824.png?v=1773345053","url":"https:\/\/afsbio.com\/products\/cdk8-polyclonal-antibody-ra23199","provider":"AFSBio Inc.","version":"1.0","type":"link"}