{"product_id":"cdkn2aip-polyclonal-antibody-e-ab-10510","title":"CDKN2AIP Polyclonal Antibody - E-AB-10510","description":"\u003cp\u003eCDKN2AIP Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-10510-60, E-AB-10510-120, E-AB-10510-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CDKN2AIP\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Calcium response factor; CARF; CARF; CDKN2A interacting protein; CDKN2A-interacting protein; Cdkn2aip; collaborates\/cooperates with ARF (alternate reading frame) protein; Collaborator of ARF; FLJ20036\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9NXV6\u003c\/p\u003e\n\n\u003cp\u003eBackground: CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 0.3 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein of human CDKN2AIP\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:200\u003c\/p\u003e\n\n \n\n \n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43136035422387,"sku":"E-AB-10510-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43136035455155,"sku":"E-AB-10510-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43136035487923,"sku":"E-AB-10510-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_82247d2d-cfb9-4daa-b78a-5810ace5746a.png?v=1709987414","url":"https:\/\/afsbio.com\/products\/cdkn2aip-polyclonal-antibody-e-ab-10510","provider":"AFSBio Inc.","version":"1.0","type":"link"}