
Major centromere autoantigen B
Centromere protein B
Size: 1.0mg
Source: Recombinant
Catalogue Number: ATC02-10
Product Information
Although at least 9 proteins are known to be associated with the centromere complex, CENP-B is normally considered to be the major centromere antigen, since autoantibodies to this protein were found to be present at high titres in all ACA sera while titres of antibodies directed at two other centromere antigens (CENP-A, CENP-C) were often much lower. CENP-B is a dimer composed of two 80-kDa subunits which binds specifically to the 17bp CENP-B box sequence that is required for the formation of a functional centromere and is located within chromosomal α-satellite DNA . CENP-B may therefore function as a trans-acting factor that regulates the formation or centromere-specific chromatin on the α-satellite DNA repeat at the nucleosome assembly level.
Autoantibodies have been reported to bind to at least 3 different epitope regions of CENP B however the 60 amino acid C-terminal region appears to constitute the major autoimmune epitope.
Clinical Indications
Systemic Sclerosis (CREST syndrome)
Systemic Lupus Erythematosus
Sjögren’s syndrome
Rheumatoid Arthritis
Primary Biliary Cirrhosis
MSDS
References
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