{"product_id":"cep131-polyclonal-antibody-e-ab-91850","title":"CEP131 Polyclonal Antibody - E-AB-91850","description":"\u003cp\u003eCEP131 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-91850-60, E-AB-91850-120, E-AB-91850-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CEP131\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: AZ1; AZI1; ZA1; CEP131\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Tags and Cell Markers\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: Q9UPN4\u003c\/p\u003e\n\n\u003cp\u003eBackground: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia\/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome\/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT and\/or intramanchette (IMT trafficking, which are important for axoneme extension and\/or cargo delivery to the nascent sperm tail (By similarity. Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication (By similarity. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human CEP131\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 117kDa\/121kDa\/122kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 145kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146621714611,"sku":"E-AB-91850-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146621747379,"sku":"E-AB-91850-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146621780147,"sku":"E-AB-91850-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_660c0e49-3a8d-4299-80ae-5072d3c4f8fd.png?v=1710298655","url":"https:\/\/afsbio.com\/products\/cep131-polyclonal-antibody-e-ab-91850","provider":"AFSBio Inc.","version":"1.0","type":"link"}