{"product_id":"cep290-f812-polyclonal-antibody-bs3831","title":"CEP290 (F812) Polyclonal Antibody-BS3831","description":"\u003cp\u003eCEP290 (F812) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3831-50, BS3831-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Centrosomal protein of 290 kDa; Cep290; Bardet-Biedl syndrome 14 protein; Cancer\/testis antigen 87; CT87; Nephrocystin-6; Tumor antigen se2-2; CEP290; BBS14; KIAA0373; NPHP6\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O15078\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes. CEP290 is ubiquitously expressed; strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5), Senior-Loken syndrome type 6 (SLSN6), Leber congenital amaurosis type 10 (LCA10) and Meckel syndrome type 4 (MKS4). Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CEP290 (F812) polyclonal antibody detects endogenous levels of CEP290 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 290 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CEP290 (F812) polyclonal antibody at 1:500 dilution\u003cbr\u003e\nLane 1: HCT116 whole cell lysate(40ug)\u003cbr\u003e\nLane 2: SGC7901 whole cell lysate(40ug)\u003cbr\u003e\nLane 3: COS-7 whole cell lysate(40ug)\u003cbr\u003e\nLane 4: A549 whole cell lysate(40ug)\u003cbr\u003e\nLane 5: CT26 whole cell lysate(40ug)\u003cbr\u003e\nLane 6: AML-12 whole cell lysate(40ug)\u003cbr\u003e\nLane 7: PC12 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 781-830 of Human CEP290.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911806292147,"sku":"BS3831-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911806324915,"sku":"BS3831-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_733b04ef-9394-40e0-ad9e-ca94172a69ae.jpg?v=1703179621","url":"https:\/\/afsbio.com\/products\/cep290-f812-polyclonal-antibody-bs3831","provider":"AFSBio Inc.","version":"1.0","type":"link"}