{"product_id":"cgk-2-polyclonal-antibody-bs67256","title":"cGK 2 Polyclonal Antibody -BS67256","description":"\u003cp\u003ecGK 2 Polyclonal Antibody\u003c\/p\u003e \n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS67256-50, BS67256-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: Q13237\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC\u003c\/p\u003e\n\n\u003cp\u003eBackground: Crucial regulator of intestinal secretion and bone growth (By similarity).\u003cbr\u003e\nPhosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity).\u003cbr\u003e\nActs downstream of NMDAR to activate the plasma membrane accumulation of GRIA1\/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1\/GLUR1 at Ser-863 (By similarity).\u003cbr\u003e\nActs as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3\/ERK1 and MAPK1\/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1\/FRA1, FOSL2\/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity).\u003c\/p\u003e\n\n\u003cp\u003eProduct: Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 217% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Recognizes endogenous levels of cGK 2 protein.\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot analysis of cGK 2 expression in A549 (A), NIH3T3 (B), HEK293T (C) whole cell lysates., Immunohistochemical analysis of cGK 2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.\u003c\/p\u003e \n\n\u003cp\u003eBioworld Molecular Weight: ~ 13 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: PRKGR2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human cGK 2. The exact sequence is proprietary.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42949502959795,"sku":"BS67256-50","price":254.38,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42949502992563,"sku":"BS67256-100","price":442.75,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_102473a6-28d4-49d5-ba0a-73626875904c.jpg?v=1704970846","url":"https:\/\/afsbio.com\/products\/cgk-2-polyclonal-antibody-bs67256","provider":"AFSBio Inc.","version":"1.0","type":"link"}