{"product_id":"chapare-mammarenavirus-nucleocapsid-protein-chapv-np-ncp0167","title":"Chapare mammarenavirus Nucleocapsid Protein (CHAPV-NP) - NCP0167","description":"\u003cp\u003eChapare mammarenavirus Nucleocapsid Protein (CHAPV-NP)\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: NCP0167\u003c\/p\u003e\n\n\u003cp\u003eProduct: Soluble protein;PBS, PH=7.4\u003c\/p\u003e\n\n\n\u003cp\u003eSwiss-Prot: EU260463.1\u003c\/p\u003e\n\n\u003cp\u003eHost: His-tag\u003c\/p\u003e\n\n\u003cp\u003eReactivity: E. coli Expression\u003c\/p\u003e\n\n\u003cp\u003eApplications: Source of infection\u003c\/p\u003e\n\n\u003cp\u003eAll Applications: Reseach\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is \u0026gt; 85% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.\u003c\/p\u003e\n\n\u003cp\u003eNotes: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes:  Carrier: pET30a-CHAPV-NP-His (C-term)\u003cbr\u003e\nVirus:Chapare virus strain 810419 segment S, complete sequence\u003c\/p\u003e\n\n\u003cp\u003eBioWorld Molecular Weight: 1686bp;47kDa\u003c\/p\u003e\n\n\u003cp\u003eSizes: 100ug, 1mg (Contact us about the 1mg size)\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"Default Title","offer_id":42887011729587,"sku":"NCP0167","price":655.54,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_21b5d83c-8531-49a7-a2f2-f281c4e24c71.jpg?v=1702314436","url":"https:\/\/afsbio.com\/products\/chapare-mammarenavirus-nucleocapsid-protein-chapv-np-ncp0167","provider":"AFSBio Inc.","version":"1.0","type":"link"}