{"product_id":"chd1l-polyclonal-antibody-bt-ap01746","title":"CHD1L Polyclonal Antibody - BT-AP01746","description":"\u003cp\u003eCHD1L Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BT-AP01746-20, BT-AP01746-50, BT-AP01746-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CHD1L encodes a DNA helicase protein involved in DNA repair. The chromodomain-helicase-DNA-binding protein 1-like converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like) is a Protein Coding gene. Diseases associated with CHD1L include fibrosarcoma of bone. Among its related pathways are Chromatin Regulation \/ Acetylation and DNA Double-Strand Break Repair. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and hydrolase activity. DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Protein: CHD1L\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eFull Product Name: CHD1L Antibody\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C for 1 year\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 101000\u003c\/p\u003e\n\n\u003cp\u003eUniProt Accession: Human: Q86WJ1; Mouse: Q9CXF7\u003c\/p\u003e\n\n\u003cp\u003eSynonyms: CHD1L; ALC1; Chromodomain-helicase-DNA-binding protein 1-like; Amplified in liver cancer protein 1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: Human: 9557; Mouse: 68058\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"BT Lab","offers":[{"title":"20μL","offer_id":45240196366515,"sku":"BT-AP01746-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"50μL","offer_id":45240196399283,"sku":"BT-AP01746-50","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45240196432051,"sku":"BT-AP01746-100","price":385.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/logo_f28d7c7c-0cd3-42bd-8be7-1631cb9e06e8.png?v=1769404950","url":"https:\/\/afsbio.com\/products\/chd1l-polyclonal-antibody-bt-ap01746","provider":"AFSBio Inc.","version":"1.0","type":"link"}