{"product_id":"chd3-rabbit-pab-a2221","title":"CHD3 Rabbit pAb - A2221","description":"\u003cp\u003eCHD3 Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A2221-20, A2221-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase\/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2\/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 227kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 280kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 1107\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q12873\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ZFH; Mi-2a; SNIBCPS; Mi2-ALPHA; CHD3\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:200 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics Nuclear Signaling, RNA Binding, Chromatin Remodeling, Immunology Inflammation.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: CHD3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189835292851,"sku":"A2221-20","price":151.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189835325619,"sku":"A2221-100","price":417.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_cb74ed4e-f05d-4e6f-a919-459568cb7b96.png?v=1766436401","url":"https:\/\/afsbio.com\/products\/chd3-rabbit-pab-a2221","provider":"AFSBio Inc.","version":"1.0","type":"link"}