{"product_id":"chd8-rabbit-pab-es9540","title":"CHD8 rabbit pAb - ES9540","description":"\u003cp\u003eCHD8 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES9540-50, ES9540-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],\u003c\/p\u003e \n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: IHC; IF\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC-p 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat; Mouse;\u003c\/p\u003e \n\n\u003cp\u003eImmunogen: Synthesized peptide derived from part region of human protein\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 283kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 57680\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q9HCK8\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus. Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201694032051,"sku":"ES9540-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201694064819,"sku":"ES9540-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_90973e15-d241-4a0e-ba54-1fd13d9de02e.png?v=1767109569","url":"https:\/\/afsbio.com\/products\/chd8-rabbit-pab-es9540","provider":"AFSBio Inc.","version":"1.0","type":"link"}