{"product_id":"chek1-polyclonal-antibody-e-ab-62039","title":"CHEK1 Polyclonal Antibody - E-AB-62039","description":"\u003cp\u003eCHEK1 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-62039-60, E-AB-62039-120, E-AB-62039-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CHEK1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CHEK1; CHK1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Epigenetics and Nuclear Signaling\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: O14757\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene belongs to the Ser\/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human CHEK1\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB \t1:500-1:2000   IHC \t1:50-1:200   IF \t1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 43kDa\/50kDa\/54kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 54kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146223288499,"sku":"E-AB-62039-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146223321267,"sku":"E-AB-62039-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146223354035,"sku":"E-AB-62039-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ec432a4b-30f8-4cdf-a5c7-3e55709d6d92.png?v=1710291886","url":"https:\/\/afsbio.com\/products\/chek1-polyclonal-antibody-e-ab-62039","provider":"AFSBio Inc.","version":"1.0","type":"link"}