{"product_id":"chicken-il12b-rabbit-pab-a25100","title":"Chicken IL12B Rabbit pAb - A25100","description":"\u003cp\u003eChicken IL12B Rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: A25100-20, A25100-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK\/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Polyclonal Antibodies\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, ELISA\u003c\/p\u003e\n\n\u003cp\u003eCross-reactivity:  Gallus\u003c\/p\u003e\n\n\u003cp\u003eProtein Weight: 36kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved Molecular Weight: 45kDa\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Recombinant protein (or fragment) .\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Gallus\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 404671\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q6X0K9\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IL-12B; IL-12p40\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003ePurity: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Avoid freeze \/ thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.\u003c\/p\u003e\n\n\u003cp\u003eRecommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg\/mL. Please optimize the concentration based on your specific assay requirements.\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Immunology, Innate, Immunity, Cytokines, Interleukins.\u003c\/p\u003e\n\n\u003cp\u003eNCBI Alias: IL12B\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20uL","offer_id":45189864652979,"sku":"A25100-20","price":179.2,"currency_code":"CAD","in_stock":true},{"title":"100uL","offer_id":45189864685747,"sku":"A25100-100","price":515.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_39ba3de8-215c-4942-a644-b30ce36474df.png?v=1766437026","url":"https:\/\/afsbio.com\/products\/chicken-il12b-rabbit-pab-a25100","provider":"AFSBio Inc.","version":"1.0","type":"link"}