{"product_id":"chop-k121-polyclonal-antibody-bs1136","title":"CHOP (K121) Polyclonal Antibody - BS1136","description":"\u003cp\u003eCHOP (K121) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μl, 100μl\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS1136-50, BS1136-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C\/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C\/EBP to classical binding sites. Inversely, the C\/EBP GADD153 dimer gains binding activity to other non classical C\/EBP stress related targets. Under normal cellμlar conditions this protein is not expressed in detectable levels, but is highly unregμlated during times of cellμlar\/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.\u003c\/p\u003e\n\n\u003cp\u003eCategory: Primary Antibody\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB, IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: DNA damage-inducible transcript 3 protein, DDIT-3, C\/EBP zeta, C\/EBP-homologous protein, CHOP, C\/EBP-homologous protein 10, CHOP-10, CCAAT\/enhancer-binding protein homologous protein, Growth arrest and DNA damage-inducible protein GADD153, DDIT3, CHOP, CHOP10, GADD153\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodification\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 100-150 of Human CHOP.\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB: 1:500~1:1000\u003cbr\u003e\nIHC: 1:50~1:200\u003cbr\u003e\nIF: 1:50~1:200\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CHOP (K121) polyclonal antibody detects endogenous levels of CHOP protein.\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight: ~ 19, 27 kDa\u003c\/p\u003e\n\n\u003cp\u003ePathway: Signaling Pathways Activating p38 MAP Kinase,\u003c\/p\u003e \n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSwissProt: P35638\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Bioworld","offers":[{"title":"50μl","offer_id":45946192134323,"sku":"BS1136-50","price":274.5,"currency_code":"CAD","in_stock":true},{"title":"100μl","offer_id":45946192167091,"sku":"BS1136-100","price":457.5,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/Bioworld_Antibody_Image_6ca33534-2486-4e91-ac84-9e0d75778258.jpg?v=1788363539","url":"https:\/\/afsbio.com\/products\/chop-k121-polyclonal-antibody-bs1136","provider":"AFSBio Inc.","version":"1.0","type":"link"}