{"product_id":"chp2-m136-polyclonal-antibody-bs3273","title":"CHP2 (M136) Polyclonal Antibody-BS3273","description":"\u003cp\u003eCHP2 (M136) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: BS3273-50, BS3273-100\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50µl, 100µl\u003c\/p\u003e\n\n\u003cp\u003eAlternative Name: Serine\/threonine-protein kinase MARK1; MAP\/microtubule affinity-regulating kinase 1; PAR1 homolog c; Par-1c; Par1c; MARK1; KIAA1477; MARK; Serine\/threonine-protein kinase MARK2 ; ELKL motif kinase 1; EMK-1; MAP\/microtubule affinity-regulating kinase 2; PAR1 homolog; PAR1 homolog b; Par-1b; Par1b; MARK2; EMK1; MAP\/microtubule affinity-regulating kinase 3; C-TAK1; cTAK1; Cdc25C-associated protein kinase 1; ELKL motif kinase 2; EMK-2; Protein kinase STK10; Ser\/Thr protein kinase PAR-1; Par-1a; Serine\/threonine-protein kinase p78; MARK3; CTAK1; EMK2; MAP\/microtubule affinity-regulating kinase 4; MAP\/microtubule affinity-regulating kinase-like 1; MARK4; KIAA1860; MARKL1\u003c\/p\u003e\n\n\u003cp\u003eProduct: Rabbit IgG, 1mg\/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2\u003c\/p\u003e\n\n\u003cp\u003eSwiss-Prot: O43745\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e \n\n\u003cp\u003eAll Applications: WB: 1:500~1:1000\u003c\/p\u003e\n\n\u003cp\u003eBackground: Calcineurin B homologous protein 2, functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+\/H+ exchange activity. Binds to and activates SLC9A1\/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin\/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.\u003c\/p\u003e\n\n\u003cp\u003ePurification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is \u0026gt; 95% (by SDS-PAGE).\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: CHP2 pAb detects endogenous levels of CHP2 protein.\u003c\/p\u003e\n\n\u003cp\u003eBioworld Molecular Weight: ~ 23 kDa\u003c\/p\u003e\n\n\u003cp\u003eNote: For research use only, not for use in diagnostic procedure.\u003c\/p\u003e\n\n\u003cp\u003eExtra Notes: Western blot (WB) analysis of CHP2 (M136) Antibody at 1:500 dilution\u003cbr\u003e\nLane 1: HEK293T whole cell lysate(40ug)\u003cbr\u003e\nLane 2: MG63 whole cell lysate(40ug)\u003cbr\u003e\nLane 3: PC12 whole cell lysate(40ug)\u003cbr\u003e\nLane 4: AML-12 whole cell lysate(40ug)\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic peptide, corresponding to amino acids 122-182 of Human MARK1\/2\/3\/4.\u003c\/p\u003e\n\n\u003cp\u003eConjugate: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eModification: Unmodified\u003c\/p\u003e","brand":"BioWorld","offers":[{"title":"50µl","offer_id":42911803146419,"sku":"BS3273-50","price":260.23,"currency_code":"CAD","in_stock":true},{"title":"100µl","offer_id":42911803179187,"sku":"BS3273-100","price":452.94,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/thumbnail_d1447bac803ec9be_11-14-09-19-51_02598251-0d12-4bd4-b2f5-0f4422aa5275.jpg?v=1703179535","url":"https:\/\/afsbio.com\/products\/chp2-m136-polyclonal-antibody-bs3273","provider":"AFSBio Inc.","version":"1.0","type":"link"}