{"product_id":"ci072-rabbit-polyclonal-antibody-es17460","title":"CI072 Rabbit Polyclonal Antibody - ES17460","description":"\u003cp\u003eCI072 Rabbit Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES17460-50, ES17460-100\u003c\/p\u003e\n\n\u003cp\u003eLead times: 1-2 weeks, if manufacturer has product in stock\u003c\/p\u003e\n\n\u003cp\u003eManufacturer\/Ship Location: China\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016],\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human, Mouse, Rat\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from human CI072 AA range: 188-238\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eTarget: CI072\u003c\/p\u003e\n\n\u003cp\u003eSpecificity: This antibody detects endogenous levels of CI072 at Human\/Mouse\/Rat\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1：500-2000\u003c\/p\u003e\n\n\u003cp\u003ePurification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml,\u003c\/p\u003e\n\n\u003cp\u003eFormlation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.\u003c\/p\u003e\n\n\u003cp\u003eExpression: Both isoforms are widely expressed, including kidney, lung, liver, heart, testis and several brain regions, such as cerebellum, Also expressed in the frontal cortex and in lymphoblasts (at protein level),\u003c\/p\u003e\n\n\u003cp\u003eMolecular Weight (Da): 53kD\u003c\/p\u003e\n\n\u003cp\u003eFields: Autophagy - animal, Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Nucleus Cytoplasm Cytoplasm, P-body Cytoplasm, Stress granule Endosome Lysosome Cytoplasmic vesicle, autophagosome Secreted Cell projection, axon Cell projection, growth cone Perikaryon Detected in the cytoplasm of neurons from brain tissue (PubMed:21944778) Detected in the nucleus in fibroblasts (PubMed:21944779) During corticogenesis, transitions from being predominantly cytoplasmic to a more even nucleocytoplasmic distribution (By similarity), [Isoform 1]: Perikaryon Cell projection, dendrite Cell junction, synapse, presynapse Cell junction, synapse, postsynapse Expressed diffusely throughout the cytoplasm and dendritic processes of cerebellar Purkinje cells Also expressed diffusely throughout the cytoplasm of spinal motor neurons, [Isoform 2]: Nuc\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eGene Name: C9orf72\u003c\/p\u003e\n\n\u003cp\u003eProtein Name: CI072\u003c\/p\u003e\n\n\u003cp\u003eMouse SwissProt Number: Q6DFW0\u003c\/p\u003e\n\n\u003cp\u003eRat Gene ID: 313155\u003c\/p\u003e\n\n\u003cp\u003eRat SwissProt Number: Q66HC3\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Biotechnology","offers":[{"title":"50μL","offer_id":46315598479539,"sku":"ES17460-50","price":186.0,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":46315598512307,"sku":"ES17460-100","price":372.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/elk_antibodies.jpg?v=1793190497","url":"https:\/\/afsbio.com\/products\/ci072-rabbit-polyclonal-antibody-es17460","provider":"AFSBio Inc.","version":"1.0","type":"link"}