{"product_id":"ck-17-monoclonal-antibody-e-ab-22039","title":"CK-17 Monoclonal Antibody - E-AB-22039","description":"\u003cp\u003eCK-17 Monoclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-22039-60, E-AB-22039-120, E-AB-22039-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CK17\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 39.1; CK 17; CK-17; Cytokeratin-17; K17; K1C17; Keratin 17; keratin 17 epitope S1; keratin 17 epitope S2; keratin 17 epitope S4; Keratin 17; type I; Keratin; Keratin type I cytoskeletal 17; keratin; type i cytoskeletal 17 [version 1]; Keratin-17; KRT17; PC; PC2; PCHC1; type I cytoskeletal 17\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Mouse\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p, IF, IP\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Monoclonal\u003c\/p\u003e\n\n\u003cp\u003eClone No.: Clone:2K5\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q04695\u003c\/p\u003e\n\n\u003cp\u003eBackground: May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial \"stem cells\". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt\/mTOR pathway. Involved in tissue repair.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthetic Peptide\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Protein A purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-1:2000, IHC 1:50-300, IF 1:50-1:200, IP 1:100-1:300\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 48kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 48kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146715103411,"sku":"E-AB-22039-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146715136179,"sku":"E-AB-22039-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146715168947,"sku":"E-AB-22039-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8411d8f3-12d7-4e75-906d-fd3c3bf90f0d.png?v=1710300651","url":"https:\/\/afsbio.com\/products\/ck-17-monoclonal-antibody-e-ab-22039","provider":"AFSBio Inc.","version":"1.0","type":"link"}