{"product_id":"claudin-19-rabbit-pab-es1986","title":"Claudin-19 rabbit pAb - ES1986","description":"\u003cp\u003eClaudin-19 rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1986-50, ES1986-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CLDN19; Claudin-19\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/10000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human CLDN19. AA range:81-130\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 23kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 149461\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: Q8N6F1\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45202047697075,"sku":"ES1986-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45202047729843,"sku":"ES1986-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_b4d04876-1004-4baa-9ed2-aa943f2a18fe.png?v=1767120657","url":"https:\/\/afsbio.com\/products\/claudin-19-rabbit-pab-es1986","provider":"AFSBio Inc.","version":"1.0","type":"link"}