{"product_id":"cleaved-casp3-p12-d175-polyclonal-antibody-e-ab-30003","title":"Cleaved-CASP3 p12 (D175) Polyclonal Antibody - E-AB-30003","description":"\u003cp\u003eCleaved-CASP3 p12 (D175) Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-30003-60, E-AB-30003-120, E-AB-30003-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Cleaved-Caspase-3 p12 (D175)\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: A830040C14Rik; Apopain; CASP-3; CASP3; CASP3; Casp3a; Caspase 3; Caspase 3; apoptosis-related cysteine peptidase; Caspase 3; apoptosis-related cysteine protease; Caspase 3; apoptosis-related cysteine protease a; Caspase-3 subunit p12; CC3; CPP-32; CPP32; CPP32B; Cysteine protease CPP32; EC 3.4.22.56; LICE; mldy; OTTHUMP00000165052; OTTHUMP00000165053; OTTHUMP00000165054; PARP cleavage protease; Procaspase3; Protein Yama; SCA 1; SCA-1; SREBP cleavage activity 1; Yama\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism, Neuroscience\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human\u003c\/p\u003e\n\n\u003cp\u003eApplication: WB, IHC-p, IF, ELISA\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n \n\n\u003cp\u003eUNIProt ID: P42574\u003c\/p\u003e\n\n\u003cp\u003eBackground: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: Synthesized peptide derived from the Internal region of human Caspase-3 p12\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: WB 1:500-2000, IHC 1:50-300, IF 1:50-300\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 32kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 20+35kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146004758707,"sku":"E-AB-30003-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146004791475,"sku":"E-AB-30003-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146004824243,"sku":"E-AB-30003-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_10619667-d800-4ffd-a58e-7ddbfabe070e.png?v=1710289641","url":"https:\/\/afsbio.com\/products\/cleaved-casp3-p12-d175-polyclonal-antibody-e-ab-30003","provider":"AFSBio Inc.","version":"1.0","type":"link"}