{"product_id":"cleaved-casp4-p20-q81-polyclonal-antibody-e-ab-30021","title":"Cleaved-CASP4 p20 (Q81) Polyclonal Antibody - E-AB-30021","description":"Cleaved-CASP4 p20 (Q81) Polyclonal Antibody\n\nSizes: 60μL, 120μL, 200μL\n\nCatalogue Numbers: E-AB-30021-60, E-AB-30021-120, E-AB-30021-200\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Cleaved-Caspase-4 p20 (Q81)\n\nTarget Synonym: Apoptotic cysteine protease Mih1\/TX; CASP-4; CASP4; CASP4; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE(rel)-II; ICE(rel)II; ICEREL II; ICH2; Mih1\/TX; Protease ICH-2; Protease TX; TX\n\nResearch Areas: Cancer, Cell Biology, Metabolism\n\nConjugation: Unconjugated\n\nHost: Rabbit\n\nSpecies Reactivity: Human\n\nApplication: WB, IHC-p, ELISA\n\nIsotype: IgG\n\nClonality: Polyclonal\n\n \n\nUNIProt ID: P49662\n\nBackground: This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is \"caspase 4, apoptosis-related cysteine peptidase\", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.\n\nConcentration: 1mg\/mL\n\nImmunogen: Synthesized peptide derived from the Internal region of human Caspase-4 p20\n\nBuffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4\n\nPurification Method: Affinity purification\n\nDilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000\n\nCalculated MW: 43kDa\n\nObserved MW: 43+22kDa\n\nStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\n\nShipping: Ice bag\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43146005151923,"sku":"E-AB-30021-60","price":200.2,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43146005184691,"sku":"E-AB-30021-120","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43146005217459,"sku":"E-AB-30021-200","price":558.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ef222976-c365-4607-8fa6-0407c25b3da9.png?v=1710289650","url":"https:\/\/afsbio.com\/products\/cleaved-casp4-p20-q81-polyclonal-antibody-e-ab-30021","provider":"AFSBio Inc.","version":"1.0","type":"link"}