{"product_id":"cleaved-caspase-1-p20-polyclonal-antibody-e-ab-93278","title":"Cleaved Caspase-1 p20 Polyclonal Antibody - E-AB-93278","description":"\u003cp\u003eCleaved Caspase-1 p20 Polyclonal Antibody\u003c\/p\u003e\n\n\u003cp\u003eSizes: 60μL, 120μL, 200μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: E-AB-93278-60, E-AB-93278-120, E-AB-93278-200\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Cleaved Caspase-1 p20\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CASP1; ICE; IL1BC; P45; caspase-1; Caspase 1\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cancer, Cell Biology, Metabolism\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Unconjugated\u003c\/p\u003e\n\n\u003cp\u003eHost: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eSpecies Reactivity: Human, Mouse\u003c\/p\u003e\n\n\u003cp\u003eApplication: IHC, IF\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P29466\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1mg\/mL\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: A synthetic peptide of human Cleaved Caspase-1 p20\u003c\/p\u003e\n\n\u003cp\u003eBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.\u003c\/p\u003e\n\n\u003cp\u003ePurification Method: Affinity purification\u003c\/p\u003e\n\n\u003cp\u003eDilution: IHC 1:50-1:100, IF 1:50-1:200\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 10kDa\/29kDa\/35kDa\/42kDa\/45kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: -20°C\/One year. Avoid freeze \/ thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: Ice bag\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"60μL","offer_id":43144022917299,"sku":"E-AB-93278-60","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"120μL","offer_id":43144022950067,"sku":"E-AB-93278-120","price":448.0,"currency_code":"CAD","in_stock":true},{"title":"200μL","offer_id":43144022982835,"sku":"E-AB-93278-200","price":742.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8865b512-1bf2-48a4-bf98-460c5df37df6.png?v=1710245433","url":"https:\/\/afsbio.com\/products\/cleaved-caspase-1-p20-polyclonal-antibody-e-ab-93278","provider":"AFSBio Inc.","version":"1.0","type":"link"}