{"product_id":"cleaved-caspase-2-p18-g170-rabbit-pab-es1016","title":"Cleaved-Caspase-2 p18 (G170) rabbit pAb - ES1016","description":"\u003cp\u003eCleaved-Caspase-2 p18 (G170) rabbit pAb\u003c\/p\u003e\n\n\u003cp\u003eSizes: 50μL, 100μL\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: ES1016-50, ES1016-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],\u003c\/p\u003e \n\n\u003cp\u003eAlternate Name: CASP2; ICH1; NEDD2; Caspase-2; CASP-2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD-2; Protease ICH-1\u003c\/p\u003e\n\n\u003cp\u003eSource: Rabbit\u003c\/p\u003e\n\n\u003cp\u003eApplications: WB; ELISA\u003c\/p\u003e\n\n\u003cp\u003eDilution: Western Blot: 1\/500 - 1\/2000. ELISA: 1\/40000. Not yet tested in other applications.\u003c\/p\u003e\n\n\u003cp\u003eReactivity: Human; Mouse; Rat\u003c\/p\u003e\n\n\u003cp\u003eImmunogen: The antiserum was produced against synthesized peptide derived from human Caspase 2 p18 N-ternal. AA range:151-200\u003c\/p\u003e\n\n\u003cp\u003eStorage and Stability: -20°C\/1 year\u003c\/p\u003e\n\n\u003cp\u003eClonality: Polyclonal\u003c\/p\u003e\n\n\u003cp\u003eIsotype: IgG\u003c\/p\u003e\n\n\u003cp\u003eConcentration: 1 mg\/ml\u003c\/p\u003e\n\n\u003cp\u003eObserved Band (KD): 18 or 35kD\u003c\/p\u003e\n\n\u003cp\u003eHuman Gene ID: 835\u003c\/p\u003e\n\n\u003cp\u003eHuman SWISS Prot NO: P42575\u003c\/p\u003e\n\n\u003cp\u003eSubcellular Location: nucleus, cytoplasm, mitochondrion, cytosol, membrane,\u003c\/p\u003e \n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ELK Bio","offers":[{"title":"50μL","offer_id":45201996972211,"sku":"ES1016-50","price":207.2,"currency_code":"CAD","in_stock":true},{"title":"100μL","offer_id":45201997004979,"sku":"ES1016-100","price":347.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_360x_a22fc564-ab25-475c-bd21-483fa861a9fd.png?v=1767119596","url":"https:\/\/afsbio.com\/products\/cleaved-caspase-2-p18-g170-rabbit-pab-es1016","provider":"AFSBio Inc.","version":"1.0","type":"link"}